Disposable Syringe Filters, PES Membrane
Sterile (SAL 10^-6) and non-sterile syringe filters with low-binding hydrophilic PES membranes — 0.22 µm sterilizing grade, 0.45 µm clarification, 13–33 mm housings. USP Class VI housing, LRV > 7.
Catalog no. SF-PES-13/25/33 (0.22 / 0.45 µm) · Ships with certificate of analysis
For Research Use OnlyOverview
At a Glance
Disposable syringe filters with a hydrophilic PES membrane in a medical-grade polypropylene housing. Attach to any standard Luer-Lock syringe and push — no power, no cleaning, no membrane changes, discard after use. The workhorse tool for sterile filtration (0.22 µm) and clarification (0.45 µm) of small-volume aqueous samples, and the standard last step before HPLC / GC injection.
Key Features
- Ready to use: individually gamma-sterilized peel packs (SAL 10^-6); non-sterile bulk also available
- Verified sterilizing performance: 0.22 µm devices show bacterial retention LRV > 7 (99.99999%, ASTM bacterial challenge); 100% integrity-tested during manufacturing
- Fast flow, low binding: hydrophilic PES delivers high flow rates with very low protein adsorption and low extractables
- Cleanroom-grade cleanliness: DNase / RNase-free, non-pyrogenic, endotoxin < 0.25 EU/mL
- Biocompatible housing: medical-grade PP certified to USP Class VI
- Membrane options: PES for aqueous and biological samples; PVDF, PTFE, Nylon, MCE, CA and SFCA for solvent-specific workflows
Configuration Options
| Attribute | Options |
|---|---|
| Membrane | PES (primary); PVDF / PTFE / Nylon / MCE / CA / SFCA |
| Pore size | 0.22 µm (sterilizing), 0.45 µm (clarification); 0.10 µm available |
| Housing diameter | 13 mm / 25–30 mm / 33 mm |
| Connectors | Inlet: female Luer-Lock; Outlet: male Luer-Slip |
| Sterility & packaging | Gamma-irradiated (SAL 10^-6), individually peel-packed; non-sterile bulk available |
| Shelf life | ~2 years at room temperature, unopened |
Typical Performance (33 mm, PES, 0.22 µm, sterile)
| Parameter | Specification |
|---|---|
| Effective membrane area | ~4.9 cm2 (24.2 mm effective diameter) |
| Flow rate | 120–146 mL/min (10 psi, 25 C, purified water) |
| Total throughput | ~100 mL (lower with particle-heavy samples) |
| Hold-up volume | < 110 µL |
| Maximum operating pressure | 6 bar (87 psi) |
| Bubble point | ~66.7–71.1 psi |
| Maximum temperature | 90 C |
| Bacterial retention | LRV > 7 (99.99999%, Brevundimonas diminuta challenge, ASTM) |
| Endotoxin | < 0.25 EU/mL (or < 2.15 EU per device, LAL test) |
| Protein binding | Very low (PES membrane) |
| Extractables | Low; passed HPLC extractables testing |
| Integrity testing | 100% of devices tested during manufacturing |
| Quality & biocompatibility | Housing PP complies with USP Class VI; ISO 9000 quality system |
Applications
- Sterile filtration of buffers, culture media, protein / enzyme solutions and additives before LNP formulation (0.22 µm)
- Clarification and particle removal for reagents and aqueous phases (0.45 µm)
- Sample clean-up before HPLC / UPLC / GC injection
- Gas and organic-solvent filtration with compatible membranes (PTFE / PVDF / Nylon)
- Small-volume bioprocess and injectable-development sample handling
Handling Notes
- Do not push finished LNP preparations through 0.22 µm filters. Nanoparticles can be retained or deformed by the membrane, altering particle size distribution and encapsulation efficiency. Use syringe filters on inputs — buffers, aqueous phases and reagents — before mixing; sterile handling of the finished product requires a dedicated aseptic process.
- Check chemical compatibility before filtering strong organic solvents (chloroform, acetone, THF, DMF etc.): PES is designed for aqueous and biological samples — switch to PTFE / PVDF / Nylon where needed, and run a small trial first.
- Throughput figures are measured with clean water; particle-loaded samples clog faster — pre-clarify heavily turbid liquids.
Research Use Only
For Research Use Only. Not for clinical, diagnostic or therapeutic use in humans.
Ordering & Documentation
Membrane, pore size, diameter and sterility combinations are confirmed per inquiry, together with COA, ISO documentation, USP Class VI evidence, FOB pricing, MOQ and lead time: Send us an inquiry
| Product | Disposable Syringe Filters, PES Membrane |
|---|---|
| Catalog no. | SF-PES-13/25/33 (0.22 / 0.45 µm) |
| Category | LNP Formulation |
| Documentation | Certificate of analysis provided with every lot |
| Intended use | For Research Use Only (RUO). Not for diagnostic or therapeutic use. |
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