LNP Microfluidic Chip — Staggered Herringbone, COC
Staggered-herringbone mixing chip in medical-grade COC for early formulation screening and small-to-medium volume LNP synthesis. 0.4–40 mL, up to 50 bar, reusable. Compatible with LNP generators S1 / S2.
Catalog no. SHM-COC-LU / SHM-COC-PL · Ships with certificate of analysis
For Research Use OnlyOverview
Overview
A staggered herringbone mixer (SHM) microfluidic chip for reproducible nanoparticle formulation. The chip is machined from a single piece of COC (cyclic olefin copolymer) — no adhesive layers in the fluid path — and mounts in standard LNP synthesis instruments.
108 herringbone grooves (18 mixing modules of 6) create chaotic advection for rapid, low-polydispersity mixing, making the chip suitable for formulation screening and for small-to-medium volume production of nucleic acid LNPs (mRNA, siRNA), liposomes and PLGA nanoparticles.
Versions
Two interface versions of the same chip — all other parameters identical:
| Version | Interface |
|---|---|
| With Luer connectors | standard Luer fittings |
| Without Luer connectors | plain ports |
Specifications
| Mixing structure | staggered herringbone (SHM) |
|---|---|
| Herringbone count | 108 (18 modules × 6) |
| Material | COC (cyclic olefin copolymer), single material, no adhesive |
| Chip dimensions | 62.2 × 41.3 mm |
| Channel width | 350–700 μm |
| Pressure resistance | 50 bar |
| Total synthesis volume | 0.4–40 mL |
| Total flow rate (TFR) | 4–40 mL/min |
| Recommended TFR | 16 mL/min |
| Total fill volume | 8.22 μL |
| Mixing structure volume | 2.09 μL |
| Reusability | reusable multiple times after simple cleaning |
| Compatible equipment | LNP generators S1, S2 |
Materials and compliance
- Single-material COC fluid path, no solvent-bonded joints
- Resistant to common organic solvents including methanol, ethanol, acetonitrile, acetone, n-propanol and isopropanol
- Materials selected in accordance with Chinese GMP (2010 Revision) and the pharmaceutical machinery materials selection guideline (20173602-T-469)
- CE marked. Quality system documentation available on request during supplier qualification.
Applications
Early-stage formulation screening; small-to-medium volume LNP synthesis; nucleic acid LNPs (mRNA / siRNA); liposomes; PLGA and other polymer nanoparticles.
| Product | LNP Microfluidic Chip — Staggered Herringbone, COC |
|---|---|
| Catalog no. | SHM-COC-LU / SHM-COC-PL |
| Category | LNP Formulation |
| Documentation | Certificate of analysis provided with every lot |
| Intended use | For Research Use Only (RUO). Not for diagnostic or therapeutic use. |
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