Flow-Focusing Glass Chip — Nanoparticle & Droplet Generation
Borosilicate glass flow-focusing chip with a cross junction for monodisperse nanoparticles and uniform droplets — 50–300 nm particles, 1–200 ms mixing, microscope-compatible, no dead volume.
Catalog no. FF-GL · Ships with certificate of analysis
For Research Use OnlyOverview
Overview
A flow-focusing chip mixes by geometry: the organic (lipid) phase enters through the central channel while two aqueous streams squeeze it from either side at a cross junction. The focused central stream thins to a few micrometres and mixes within milliseconds, self-assembling into particles as the phases meet.
The result is highly uniform, stable particles — and with hydrophilic or hydrophobic surface treatment, the same chip generates water-in-oil or oil-in-water droplets.
Specifications
| Mixing structure | flow focusing (cross junction) |
|---|---|
| Material | borosilicate glass (B270 / Borofloat type) |
| Main channel width | 350 μm |
| Main channel depth | 125 μm |
| Mixing channel width | 125 μm |
| Mixing channel depth | 50 μm |
| Mixing steps | 12 |
| Particle size | 50–300 nm |
| Mixing time | 1–200 ms |
| Other features | no dead volume, smooth channel surfaces, microscope-compatible |
| Part number | FF-GL |
Key features
- Uniform, stable particles — flow focusing produces monodisperse nanoparticles and droplets
- Fast mixing, short distance — complete mixing within 1–200 ms in a compact structure
- Robust glass construction — resistant to acids, alkalis, high temperature and organic solvents; low fluorescence background, minimal adsorption of biomolecules, high pressure tolerance
- Selectable surface chemistry — hydrophilic or hydrophobic treatment for water-in-oil or oil-in-water droplets to match the experiment
- No dead volume — ideal for small volumes and precious samples
Applications
LNP, liposome and PLGA nanoparticle synthesis; droplet and microsphere generation (40–200 μm droplets); digital PCR and single-cell encapsulation workflows requiring uniform droplets; formulation R&D and small-volume preparation.
Notes
- Channel dimensions vary between manufacturers; the figures above reflect our current glass chip specification — request the datasheet for your specific lot at enquiry.
- Micropillar mixing structures are not stocked as standard; custom layouts are quoted on request subject to factory confirmation.
- Certification documents are available on request and verifiable by certificate number.
| Product | Flow-Focusing Glass Chip — Nanoparticle & Droplet Generation |
|---|---|
| Catalog no. | FF-GL |
| Category | LNP Formulation |
| Documentation | Certificate of analysis provided with every lot |
| Intended use | For Research Use Only (RUO). Not for diagnostic or therapeutic use. |
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