In Vivo T-Cell Targeted tLNP Control Kits (Antibody-Conjugated LNP)
Antibody-conjugated LNPs that find and transfect T cells directly in circulation — up to 99.5% positive rate on resting CD8+ T cells. Ready-to-use control kits with EGFP / FLuc / mCherry / Cre reporter mRNA for in vivo CAR-T / TCR-T programmes.
Catalog no. TD-TCI series · Ships with certificate of analysis
For Research Use OnlyOverview
Overview
T cells are the workhorse of CAR-T and TCR-T immunotherapy — and notoriously resistant to transfection: plain LNPs barely reach them. These kits solve the problem with antibody-conjugated LNPs (tLNP): targeting antibodies on the particle surface recognise T cells and deliver the RNA payload with high specificity. Administered in vivo, the particles find and transfect T cells directly in circulation.
Key data
| Resting CD8+ T-cell transfection | up to 99.5% positive rate |
|---|---|
| Format | ready-to-use — no LNP preparation required |
| Use | in vivo T-cell targeted delivery (animal studies) |
Range — control kits
Each control kit ships with one reporter mRNA for validating T-cell transfection. Two lipid series, four reporters each:
| Series | Reporter mRNA |
|---|---|
| Ab-L829-tLNP | EGFP |
| Ab-L829-tLNP | FLuc |
| Ab-L829-tLNP | mCherry |
| Ab-L829-tLNP | Cre |
| Ab-LN29-tLNP | EGFP |
| Ab-LN29-tLNP | FLuc |
| Ab-LN29-tLNP | mCherry |
| Ab-LN29-tLNP | Cre |
Sizes (per kit)
| Size | Volume |
|---|---|
| 25 μg | 250 μL |
| 100 μg | 1000 μL |
In vivo or ex vivo?
These kits target T cells inside the body. If you engineer harvested T cells in culture (ex vivo CAR-T, functional studies), see our Ex Vivo T-Cell Transfection Kit.
Notes
- Control kits contain reporter mRNA (EGFP / FLuc / mCherry / Cre) for validating T-cell transfection — they are not universal reagents for customer-supplied RNA. Ask us about custom payloads.
- The 99.5% figure refers to resting CD8+ T cells; our ex vivo kit reports ≥85% on day-3 CD3/CD28-activated primary T cells — different experimental conditions, compare with care.
- For Research Use Only. Not a drug and not a medical device; supplied exclusively for research applications.
- Certification documents available on request and verifiable by certificate number. FOB pricing, MOQ and lead time quoted at enquiry.
| Product | In Vivo T-Cell Targeted tLNP Control Kits (Antibody-Conjugated LNP) |
|---|---|
| Catalog no. | TD-TCI series |
| Category | Targeted Delivery |
| Documentation | Certificate of analysis provided with every lot |
| Intended use | For Research Use Only (RUO). Not for diagnostic or therapeutic use. |
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