Ionizable Lipid — MC3 Type (D-Lin-MC3-DMA, Research Grade)

Overview

Overview

MC3 (D-Lin-MC3-DMA) is the first-generation classic: the ionizable lipid of Onpattro, the first approved siRNA drug. It defined the low-toxicity, high-efficiency template that later ionizable lipids are measured against — a pKa of about 6.44 remains a reference point in lipid design, and a large share of published LNP work uses MC3 formulations as the benchmark arm.

This is a research-grade equivalent of that structure — not the original manufacturer's product — supplied strictly for research use.

Also available: ALC-0315 type for vaccine-era formulations, and our proprietary ionizable lipid for commercial-track programmes free of foreign-patent exposure.

Key specifications

Pack sizes

Larger pack sizes are quoted at enquiry.

Key features

• The first-generation benchmark — the Onpattro lipid; the control arm countless studies run against, with steady named demand from literature reproduction
• Earliest patent expiry of the three benchmark structures — approximately 2028–2030, ahead of SM-102 / ALC-0315 (2036+): the structure most watched by teams planning commercial pipelines
• pH-responsive performance — tight nucleic-acid complexation at low pH, near-neutral at physiological pH, strong endosomal escape
• Domestic capacity, import-beating pricing — ten-kilogram-per-batch production at the source factory, from 1 g research packs to 100 g pilot quantities
• Complete quality system — ISO 9001 / 13485, ICH-Q7A production, CDE registration and FDA DMF filing in place; consistent between batches

Applications

siRNA and oligonucleotide LNP research on Onpattro-aligned MC3 formulations; mRNA delivery research; CRISPR and gene-editing delivery; method reproduction, control experiments and new-lipid screening against the MC3 benchmark; gram-to-hundred-gram supply with custom structures on request.

Notes

• Patented structure — research use only. The MC3 structure remains under foreign patent until approximately 2028–2030, and commercial use requires a licence from the patent holder. This material is supplied exclusively for research applications; commercial-track enquiries are assessed case by case.
• Supplied as an MC3 type equivalent — not the original manufacturer's product. No therapeutic or diagnostic claims are made or permitted.
• Cold-chain product — stored at −20 °C and shipped on dry ice; export packaging and transport conditions confirmed at order.
• Catalogue codes, filing references, COA, MSDS, ISO certificates, FOB pricing, MOQ and lead time are provided one-to-one at enquiry.